Methadone

Methadone is a long acting µ-opioid receptor agonist with potent central analgesic, sedative and antitussive actions. Methadone inhibits ascending pain pathways, alters perception of and response to pain, and produces generalized CNS depression. It is used as an analgesic for the relief of moderate to severe pain and is used in the detoxification treatment of opioid dependence.  When used to treat addiction, methadone suppresses withdrawal symptoms for 24 to 36 hours. When administered orally, methadone is rapidly absorbed from the gastrointestinal tract and can be detected in the blood within 30 minutes. The half-life of (R,S)-methadone is 15-60 hours, and 10-40 hours for (R)-methadone.

Whole Blood
Post Mortem Blood
Urine
Oral Fluid
Hair
Meconium
Vitreous Humor
Tissue

Cross Reactivity

Analyte Compound
Cross Reactivity %
CR%
Methadone
LOD: 0.18 ng/mL
Methadone 100
EDDP
<1
EMDP
<1

All data in the above table refers to our whole blood matrix.

Microplate Readers Available

Product ds2 7

DS2

  • Fully automated compact reader
  • Processes 100 samples per run
  • Ideal for routine drug detection


Product elx800 cutout tox logo

ELx800

  • Semi-automated robust microplate reader
  • Reads 96 wells in 30 seconds
  • Ideal for routine drug detection

UK: +44 (0)28 9442 2413
USA: +1 304 728 2890